Reading and rewriting the genome
Three connected lines of work: reading DNA, RNA, and epigenetic information — including screening-based studies of mechanism — building the software that makes those measurements usable, and turning both into therapies.
DNA / RNA analysis and epigenetics
We develop methods to analyze the information embedded in DNA and RNA. Our research connects data across genetics and epigenetics — sequences, large mutations, and base modifications — and uses pooled screening to trace how those changes drive cellular and disease mechanisms.
DNA/RNA analysis software
We build software for analyzing DNA and RNA information — tools for newly developed methods, and tools that work around the limits of existing ones. They are designed as web platforms so that anyone can use them without installing anything.
CRISPR & prime editing gene therapy
We develop CRISPR-based gene therapies with a focus on validating their performance and safety. Our targets include genetic disorders and non-genetic disease alike, and the same approaches let us study disease mechanisms directly in human cells.
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